The first generation Nissan Murano was unveiled in production form for the model year of 2003, at the 2002 New York International Auto Show. It is powered by a 3.5-liter (VQ35DE) V6 producing 183 kW (245 hp) and 334 N⋅m (246 lbf⋅ft), also used in several other Nissan models like the Altima, Maxima, and Nissan 350Z, but specifically tuned for use in the Murano. Available with standard front-wheel-drive (FWD) and optional all-wheel-drive (AWD), the Nissan Murano is one of the largest vehicles using a continuously variable transmission (CVT). Fuel economy was rated at 13 L/100 km; 22 mpg‑imp (18 mpg‑US) in the city and 10 L/100 km; 28 mpg‑imp (23 mpg‑US) on the highway (same mpg FWD and AWD on the new EPA specifications).[dead link][9]

Production started in the middle of May 2002, and the first vehicles shipped in early June for the United States and mid-July for Canadian markets. Sales in Europe started in 2004, following its European premiere at the 2004 Geneva Motor Show.[10] An independent suspension on all wheels was used for class-leading ride and handling.[11]

A full set of airbags, steel-reinforced cabin, and head restraints were safety features designed to protect the interior while VDC, ABS, electronic brakeforce distribution and brake assist were mechanical safety features. VDC incorporates a form of traction control.

The Murano received a crash test rating of five stars in all categories but vehicle rollover (four stars) from the United States National Highway Traffic Safety Administration (NHTSA).[12]

For the model year of 2006 in North America, the Murano received some updates in the form of LED tail lamps and turn signals, standard color information screen, available backup camera (standard in Canada for all models), GPS and a restyled front end with some minor trim updates. September 2004, the Murano was introduced in Japan, replacing the Bassara MPV and exclusive to Nissan Red Stage locations, with a further introduction at Nissan Blue Stage locations in October, replacing the Terrano.

In Japan, the Murano is equipped with many optional features found in North America as standard equipment on Japanese models, including Nissan’s GPS and internet-based navigation system called CarWings. Japanese models were available with two engine choices, the 3.5L V6 engine mated to a CVT transmission or a 2.5 L four-cylinder engine with a 4-speed automatic transmission.